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Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 83-93 doi: 10.1007/s11684-019-0682-z

Abstract: been demonstrated to cause an S492R mutation in EGFR.However, little is known about the biological function of S492R EGFR.Our study indicated that EGFR and S492R EGFR accelerate the growth of CRC cells in vitro and <, can bind efficiently to S492R EGFR.EGFR than mAb C225. mAb CH12 obviously suppressed the growth of CRC xenografts with S492R EGFR mutations

Keywords： S492R EGFR ectodomain mutation     colorectal cancer     mAb CH12     immunnotherapy    

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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 701-713 doi: 10.1007/s11684-022-0951-0

Abstract: management of the inevitable acquired resistance to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs), such as osimertinib, which have shown remarkable success inthe treatment of advanced NSCLC with EGFR activating mutations, in order to achieve maximal responsehas been clearly shown that effective induction of apoptosis is a key mechanism for third generation EGFR-TKIsmeans promises an effective strategy for the management of acquired resistance to third generation EGFR-TKIs

Keywords： acquired resistance     EGFR inhibitor     apoptosis     lung cancer    

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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 383-388 doi: 10.1007/s11684-016-0488-1

Abstract:

The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming theThree generations of EGFR TKIs have been used in clinical applications. C797S mutation, EGFR L718Q mutation, and amplifications of HER-2,inhibitor that overcomes T790M- and C797S-mediated resistance.as the latest development of EAI045 as a fourth-generation EGFR inhibitor.

Keywords： EGFR     tyrosine kinase inhibitor     AZD9291     EAI045    

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Evaluating R&D efficiency of China’s listed lithium battery enterprises

Frontiers of Engineering Management   Pages 473-485 doi: 10.1007/s42524-022-0213-5

Abstract: Promoting the growth of the lithium battery sector has been a critical aspect of China’s energy policyHowever, despite significant support on research and development (R&D) investments that have resultedResults revealed little indication of a meaningful improvement in R&D efficiency throughout our sampleHowever, during this period, a significant increase in R&D expenditure was witnessed.leading players seemed superior because their average efficiency scores were higher than the industry’s

Keywords： Data Envelopment Analysis     R&D investment efficiency     China’s listed lithium battery enterprises     technical    

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Improved R /S Method and Analysis and Forecast to China Fire Data

Fu Yuhua,Fu Anjie

Strategic Study of CAE 2004, Volume 6, Issue 5,   Pages 39-44

Abstract:

This paper discusses some improvements for the R/S analysis method (rescaled range analysis) in engineeringdifference of Hurst exponent AH is introduced to judge the possibility whether or not the next year'sFor the R/S analysis of the calculated Hurst exponents, a new group of Hurst exponent H1,iAccording to the fire numbers from 1950〜1999, the fire number of year 2000 is forecasted with R/S method

Keywords： R/S analysis     rescaled range analysis     high order Hurst exponent     total fire number of whole country     forecast    

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Improvement potential of today’s WEEE recycling performance: The case of LCD TVs in Belgium

Paul Vanegas, Jef R. Peeters, Dirk Cattrysse, Wim Dewulf, Joost R. Duflou

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 5, doi: 10.1007/s11783-017-1000-0

Abstract: Waste of electrical and electronic equipment (WEEE) constitutes one of the most relevant waste streams because of the quantity and presence of valuable materials. However, there is limited knowledge on the resource potential of urban mining WEEE, as data on material composition, and the efficiency of current recycling treatments are still scarce. In this article, an evaluation of the recycling performance at a national level for one of the fastest growing e-waste streams: LCD TVs is carried out through the following four steps. Firstly, material characterisation is performed by means of sampling of the waste stream. Secondly, a material flow analysis is conducted by evaluating the separation performance of a recycling plant in Belgium. Thirdly, the recovered economic value and avoided environmental impact (EI) of the analysed recycling system is assessed. Finally, the potential of urban mining for Belgium is forecasted. The analysis shows that while recycling performance for ferrous metals and aluminium are relatively high; there is substantial room to better close the material loops for precious metals (PM) and plastics. PMs and plastics account for 66 % of the economic value in LCD TVs and 57% of the EI. With the current, commonly applied recycling technology only one-third of the PM and housing plastics are recycled; meaning that for these materials, at a national level for Belgium, there is a potential for improvement that represents 3.3 million euros in 2016 and 6.8 million euros in 2025.

Keywords： Recycling     Waste of electrical and electronic equipment (WEEE)     Material flow analysis     LCD TVs     Precious metals     Plastics    

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Response in piled raft foundation of tall chimneys under along-wind load incorporating flexibility of soil

R. JAYALEKSHMI,S.V. JISHA,R. SHIVASHANKAR

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 3,   Pages 307-322 doi: 10.1007/s11709-015-0288-8

Abstract: chimneys were assumed to be located in terrain category 2 and subjected to a maximum wind speed of 50 m/s

Keywords： finite element method     piled raft     tall chimney     soil-structure interaction     along-wind load    

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Techno-economic evaluation of wind energy in southwest Nigeria

Muyiwa S. ADARAMOLA, Olarenwaju M. OYEWOLA, Olayinka S. OHUNAKIN, Rufus R. DINRIFO

Frontiers in Energy 2012, Volume 6, Issue 4,   Pages 366-378 doi: 10.1007/s11708-012-0205-y

Abstract: In this study, an analysis of the wind energy potential in the southwest geo-political region of Nigeria was conducted. A 37-year (1971–2007) wind speed data set measured at 10 m height, obtained from eight meteorological stations within the region was analyzed using a 2-parameter Weibull function. Besides, a techno-economic evaluation of large wind energy conversion systems with power ratings ranging from 0.6 to 2 MW at different hub heights based on the levelized unit cost of electricity was made for the different sites considered. The result showed that electricity cost varied from 0.06997 and 0.11195 $/(kW·h) to 2.86611 and 4.58578 $/(kW·h) at limit values of turbine specific cost band intervals of 1000 and 1600 $/kW. It was further shown that Lagos, having the highest accumulated power outputs of 430.10 kW/a from DeWind D7 at 70 m hub height, is the most preferred for economically usable power generation in terms of the levelized unit cost.

Keywords： mean wind speed     Weibull distributions     wind turbine     techno-economic analysis     southwest geopolitical region     Nigeria    

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Estimation of relations among hysteretic response measures and design parameters for RC rectangular shear walls

R. BANAN, Mo. R. BANAN, S. FARHADI

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 1,   Pages 3-15 doi: 10.1007/s11709-017-0418-6

Abstract: Seismic design of RC structures requires estimation of structural member behavioral measures as functions of design parameters. In this study, the relations among cyclic behavioral measures and design parameters have been investigated for rectangular RC shear walls using numerical simulations calibrated based on the published laboratory tests. The OpenSEES numerical simulations modeling of plastic hinge hysteretic behavior of RC shear walls and estimation of empirical relations among wall hysteretic indices and design parameters are presented. The principal design parameters considered were wall dimensions, axial force, reinforcement ratios, and end-element design parameters. The estimated hysteretic response measures are wall effective stiffness, yield and ultimate curvatures, plastic moment capacity, yield and ultimate displacements, flexural shear capacity, and dissipated energy. Using results of numerous analyses, the empirical relations among wall cyclic behavioral measures and design parameters are developed and their accuracy is investigated.

Keywords： RC wall hysteretic measures     RC wall design parameters     empirical relations     numerical simulations     RC rectangular wall plastic hinge    

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Design concepts of an aircraft wing: composite and morphing airfoil with auxetic structures

P R BUDARAPU,Sudhir Sastry Y B,R NATARAJAN

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 4,   Pages 394-408 doi: 10.1007/s11709-016-0352-z

Abstract: components and (ii) unique deformation characteristics, which produce a theoretical in-plane Poisson’s

Keywords： wing design     aerodynamic loads     morphing airfoil     auxetic structures     negative Poisson’s ratio    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: Overall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5Moreover, this patient carries a p.Gly970Asp mutation, thus confirming the high-frequency of this mutation

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Detection of void and metallic inclusion in 2D piezoelectric cantilever beam using impedance measurements

S. SAMANTA, S. S. NANTHAKUMAR, R. K. ANNABATTULA, X. ZHUANG

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 3,   Pages 542-556 doi: 10.1007/s11709-018-0496-0

Abstract: The aim of current work is to improve the existing inverse methodology of void-detection based on a target impedance curve, leading to quick-prediction of the parameters of single circular void. In this work, mode-shape dependent shifting phenomenon of peaks of impedance curve with change in void location has been analyzed. A number of initial guesses followed by an iterative optimization algorithm based on univariate method has been used to solve the problem. In each iteration starting from each initial guess, the difference between the computationally obtained impedance curve and the target impedance curve has been reduced. This methodology has been extended to detect single circular metallic inclusion in 2D piezoelectric cantilever beam. A good accuracy level was observed for detection of flaw radius and flaw-location along beam-length, but not the precise location along beam-width.

Keywords： piezoelectricity     impedance curve     mode shapes     inverse problem     flaw detection     curve shifting    

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Correlations for estimating solar radiation using sunshine hours and temperature measurement in Osogbo, Osun State, Nigeria

S. OHUNAKIN, M. S. ADARAMOLA, O. M. OYEWOLA, R. O. FAGBENLE

Frontiers in Energy 2013, Volume 7, Issue 2,   Pages 214-222 doi: 10.1007/s11708-013-0241-2

Abstract: In this study, the global solar radiation on horizontal surface in Osogbo, Osun state, Nigeria was analyzed using 11-year data (1997–2007). Correlations using linear and quadratic expressions were developed to relate the global solar radiation on horizontal surface based on relative sunshine hours and temperature measurements for evaluating the monthly average daily global solar radiation. The calculated monthly clearness index values indicate that the prevailing weather condition in Osogbo is heavily overcast. All the developed quadratic correlations gave better correlation coefficients (0.834, 0.872 and 0.823 respectively) than the linear models. However, the Hargreaves and Samani related based quadratic model gave the best among the three developed quadratic expressions and is therefore suggested for estimating the monthly global radiation in this site and its surroundings.

Keywords： global solar radiation     Hargreaves model     sunshine hour     ambient temperatures     Osogbo    

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Kinematical synthesis of an inversion of the double linked fourbar for morphing wing applications

AGUIRREBEITIA, R. AVILéS, I. FERNáNDEZ, M. ABASOLO

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 1,   Pages 17-32 doi: 10.1007/s11465-013-0364-5

Abstract:

This paper presents the kinematical features of an inversion of the double linked fourbar for morphing wing purposes. The structure of the mechanism is obtained using structural synthesis concepts, from an initial conceptual schematic. Then, kinematic characteristics as instant center of rotation, lock positions, dead point positions and uncertainty positions are derived for this mechanism in order to face the last step, the dimensional synthesis; in this sense, two kinds of dimensional synthesis are arranged to guide the wing along two positions, and to fulfill with the second one some aerodynamic and minimum actuation energy related issues.

Keywords： morphing wing     structural synthesis     dimensional synthesis     geometrical kinematics    

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Design of efficient Pt-based electrocatalysts through characterization by X-ray absorption spectroscopy

Nebojsa S. MARINKOVIC, Kotaro SASAKI, Radoslav R. ADZIC

Frontiers in Energy 2017, Volume 11, Issue 3,   Pages 236-244 doi: 10.1007/s11708-017-0487-1

Abstract: A method is described to determine the internal structure of electrocatalyst nanoparticles by X-ray absorption spectroscopy (XAS). The nondestructive spectroscopic technique typically utilizing synchrotron radiation as the source measures changes in the X-ray absorption coefficient as a function of energy. The bulk technique has found its use for materials characterization in all scientific areas, including nanomaterials. The analysis of the internal structure of nanoparticles reveals interatomic distances and coordination numbers for each element, and their values and mutual relations indicate whether the elements form a homogeneous or heterogeneous mixture. The core-shell heterogeneous structure in which certain elements are predominantly located in the core, and others form the encapsulating shell is of particular importance in catalysis and electrocatalysis because it may reduce the amount of precious metals in nanoparticles by replacing the atoms in the core of nanoparticles with more abundant and cheaper alternatives. The examples of nanoparticle structures designed in the laboratory and the approach to model efficient catalysts through systematic analysis of XAS data in electrochemical systems consisting of two and three metals are also demonstrated.

Keywords： X-ray absorption spectroscopy     EXAFS     XANES     nanocatalysts     core shell    

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Title Author Date Type Operation

Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Journal Article

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Journal Article

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Journal Article

Evaluating R&D efficiency of China’s listed lithium battery enterprises

Journal Article

Improved R /S Method and Analysis and Forecast to China Fire Data

Fu Yuhua,Fu Anjie

Journal Article

Improvement potential of today’s WEEE recycling performance: The case of LCD TVs in Belgium

Paul Vanegas, Jef R. Peeters, Dirk Cattrysse, Wim Dewulf, Joost R. Duflou

Journal Article

Response in piled raft foundation of tall chimneys under along-wind load incorporating flexibility of soil

R. JAYALEKSHMI,S.V. JISHA,R. SHIVASHANKAR

Journal Article

Techno-economic evaluation of wind energy in southwest Nigeria

Muyiwa S. ADARAMOLA, Olarenwaju M. OYEWOLA, Olayinka S. OHUNAKIN, Rufus R. DINRIFO

Journal Article

Estimation of relations among hysteretic response measures and design parameters for RC rectangular shear walls

R. BANAN, Mo. R. BANAN, S. FARHADI

Journal Article

Design concepts of an aircraft wing: composite and morphing airfoil with auxetic structures

P R BUDARAPU,Sudhir Sastry Y B,R NATARAJAN

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Detection of void and metallic inclusion in 2D piezoelectric cantilever beam using impedance measurements

S. SAMANTA, S. S. NANTHAKUMAR, R. K. ANNABATTULA, X. ZHUANG

Journal Article

Correlations for estimating solar radiation using sunshine hours and temperature measurement in Osogbo, Osun State, Nigeria

S. OHUNAKIN, M. S. ADARAMOLA, O. M. OYEWOLA, R. O. FAGBENLE

Journal Article

Kinematical synthesis of an inversion of the double linked fourbar for morphing wing applications

AGUIRREBEITIA, R. AVILéS, I. FERNáNDEZ, M. ABASOLO

Journal Article

Design of efficient Pt-based electrocatalysts through characterization by X-ray absorption spectroscopy

Nebojsa S. MARINKOVIC, Kotaro SASAKI, Radoslav R. ADZIC

Journal Article